CAMKIV Recombinant Rabbit Monoclonal Antibody [JB33-13]

About this product

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.

Specifications

Catalog number

ET7107-96

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Brain Ca (2+) calmodulin dependent protein kinase type 4 antibody Brain Ca (2+) calmodulin dependent protein kinase type IV antibody Brain Ca++-calmodulin dependent protein kinase type IV antibody Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody Calcium/calmodulin dependent protein kinase IV antibody Calcium/calmodulin dependent protein kinase type IV antibody Calcium/calmodulin-dependent protein kinase type IV antibody CAM kinase 4 antibody CAM kinase GR antibody CAM kinase IV antibody CAM kinase-GR antibody CaMK 4 antibody CAMK GR antibody CaMK IV antibody Camk4 antibody CaMKGR antibody IV antibody KCC4_HUMAN antibody MGC36771 antibody

Abbreviation

CaMK IV, CAMK4, CAMK, CAMK-GR, CAMKIV

Swiss Prot

Q16566 Human, P08414 Mouse, P13234 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human CAMKIV aa 360-473 / 473.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, Hela, SH-SY5Y, 293T, rat brain tissue, rat cerebellum tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 52 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes