hnRNP Q Recombinant Rabbit Monoclonal Antibody [JG35-72]

About this product

Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

Specifications

Catalog number

ET7108-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

cytoplasmic RNA-interacting protein antibody dJ3J17.2 antibody Glycine and tyrosine rich RNA binding protein antibody Glycine- and tyrosine-rich RNA-binding protein antibody GRY RBP antibody GRY-RBP antibody GRYRBP antibody Heterogeneous nuclear ribonucleoprotein Q antibody hnRNP Q antibody HNRPQ antibody HNRPQ_HUMAN antibody HNRPQ1 antibody NS1 associated protein 1 antibody NS1-associated protein 1 antibody NSAP1 antibody pp68 antibody RP1 3J17.2 antibody Synaptotagmin binding cytoplasmic RNA interacting protein antibody Synaptotagmin-binding antibody Syncrip antibody

Abbreviation

hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1

Swiss Prot

O60506 Human, Q7TP47 Rat, Q7TMK9 Mouse

Cellular Locus

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome.

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide within Human hnRNP Q aa 574-623 / 623.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, IF-Tissue

Positive Control

K562 cell lysates, rat brain tissue lysates, LOVO, SiHa, rat testis tissue, human thyroid tissue, human breast tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes