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![Transferrin Receptor 2 Recombinant Rabbit Monoclonal Antibody [JG58-34] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81a67/imageurl/et7108-21.webp)
Product details
Catalog number ET7108-21
Price for ET7108-21
Size / count 100 µL
Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.
The catalog number for Transferrin Receptor 2 Recombinant Rabbit Monoclonal Antibody [JG58-34] is ET7108-21.
Transferrin Receptor 2 Recombinant Rabbit Monoclonal Antibody [JG58-34] is available in the following size(s): 100 µL.
Transferrin Receptor 2 Recombinant Rabbit Monoclonal Antibody [JG58-34] is currently made to order / not held in immediate stock. Contact us for lead time.
Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly re
Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.
Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.
Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.
