FHL2 Recombinant Rabbit Monoclonal Antibody [JG36-42]

About this product

The four-and-a-half-LIM domain (FHL) proteins include FHL-1 (SLIM1), FHL-2 (SLIM3), FHL-3 (SLIM2) and FHL-4. The signature "half-domain", a single zinc finger domain located in the N-terminal region, differentiates FHLs from other LIM-only proteins, which have numbers of zinc fingers. Specific combinations of FHL proteins elicit selective activation of both CREB and CREM. Skeletal and cardiac muscle express FHL-1 in high levels as compared to the low level of expression in smooth muscle of the colon, small intestine and prostate. FHL-1 localizes to the cytosol of myoblasts, myotubes, and differentiated myocytes. FHL-2 is also located in cardiac and skeletal muscle, as well as in placenta and ovary tissues. FHL-3 is found in skeletal muscle, but absent in cardiac muscle. FHL-4 is expressed exclusively by the seminiferous epithelium of the testis, which suggests that FHL-4 is involved in spermatogenesis. The genetic loci for FHLs vary considerably despite similiar amino acid sequences among the FHL group.

Specifications

Catalog number

ET7108-33

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AAG 11 antibody AAG11 antibody Aging associated gene 11 antibody Down regulated in rhabdomyosarcoma LIM protein antibody Downregulated in rhabdomyosarcoma LIM protein antibody DRAL antibody FHL 2 antibody FHL-2 antibody Fhl2 antibody FHL2 protein antibody FHL2_HUMAN antibody Four and a half LIM domain protein 2 antibody Four and a half LIM domains 2 antibody Four and a half LIM domains protein 2 antibody KIAA0990 antibody LIM domain protein DRAL antibody Skeletal muscle LIM protein 3 antibody Skeletal muscle LIM-protein 3 antibody SLIM 3 antibody SLIM-3 antibody SLIM3 antibody

Abbreviation

FHL-2, SLIM-3, FHL2, DRAL, SLIM3

Swiss Prot

Q14192 Human, O70433 Mouse, O35115 Rat

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human FHL2 aa 30-280 / 279.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

Rat heart tissue lysate, mouse heart tissue lysate, rat heart tissue, human fetal heart, mouse heart.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 32 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes