SUV39H2 Recombinant Rabbit Monoclonal Antibody [JG36-55]

About this product

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Specifications

Catalog number

ET7108-37

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FLJ23414 antibody H3 K9 HMTase 2 antibody H3-K9-HMTase 2 antibody Histone H3 K9 methyltransferase 2 antibody Histone H3-K9 methyltransferase 2 antibody Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody Histone lysine N methyltransferase SUV39H2 antibody Histone-lysine N-methyltransferase SUV39H2 antibody KMT1B antibody Lysine N methyltransferase 1B antibody Lysine N-methyltransferase 1B antibody sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody Su (var)3 9 Drosophila homolog of 2 antibody Su (var)3 9 homolog 2 antibody Su (var)3-9 homolog 2 antibody Suppressor of variegation 3 9 homolog 2 antibody Suppressor of variegation 3-9 homolog 2 antibody Suv39h2 antibody SUV92_HUMAN antibody

Abbreviation

H3-K9-HMTase 2, Su (var)3-9 homolog 2, SUV39H2, KMT1B

Swiss Prot

Q9H5I1 Human, Q9EQQ0 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human SUV39H2 aa 361-410 / 410.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

U-2 OS cell lysate, A549 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, NIH/3T3 cell lysate, Mouse testis tissue lysate, Rat testis tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 47 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes