Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33]

Catalog number ET7108-38

Price for ET7108-38

Size / count 100 µL

About this product

The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites.

Specifications

Catalog number: ET7108-38
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Anterior pharynx defective 2 antibody APH 2 antibody APH2 antibody ATAG1874 antibody KIAA0253 antibody Ncstn antibody NCT antibody NICA_HUMAN antibody Nicastrin antibody RP11 517F10.1 antibody RP11517F101 antibody
Abbreviation: NCSTN, KIAA0253
Swiss Prot: Q92542 Human, P57716 Mouse
Cellular Locus: Membrane, Cytoplasmic vesicle membrane, Melanosome.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recomninant protein within Human Nicastrin aa 5-112 / 709.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: THP-1 cell lysates, NIH/3T3 cell lysate, Neuro-2a cell lysate, Mouse brain tissue lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 78 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33]?

The catalog number for Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] is ET7108-38.

What sizes are available for Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33]?

Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] is available in the following size(s): 100 µL.

Is Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] in stock?

Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] used for?

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.