Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] — image 1 of 3

Product details

Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31]

Catalog number ET7108-47

Price for ET7108-47

Size / count 100 µL

About this product

Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex.

Specifications

Catalog number: ET7108-47
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Cul2 antibody CUL 2 antibody CUL-2 antibody CUL2 antibody CUL2_HUMAN antibody cullin 2 antibody cullin homolog 2 antibody Cullin-2 antibody MGC131970 antibody
Abbreviation: CUL-2, CUL2
Swiss Prot: Q13617 Human, Q9D4H8 Mouse,
Cellular Locus: Cytoplasm. Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within N-terminal Human Cullin 2 .
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IP
Positive Control: PC-3M cell lysate, k562 tissue lysate, rat testis tissue, human tonsil tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;IP: 1:10-1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 89 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31]?

The catalog number for Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] is ET7108-47.

What sizes are available for Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31]?

Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] is available in the following size(s): 100 µL.

Is Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] in stock?

Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Cullin 2 Recombinant Rabbit Monoclonal Antibody [JG72-31] used for?

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.