RanGAP1 Recombinant Rabbit Monoclonal Antibody [JG37-41]

About this product

The small Ras related protein Ran, also called TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The abundant GEF RCC1 (regulator of chromosome condensation 1) increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.

Specifications

Catalog number

ET7108-48

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Fug 1 antibody Fug1 antibody GTPase-activating protein, RAN, 1 antibody KIAA1835 antibody MGC20266 antibody OTTHUMP00000028918 antibody OTTHUMP00000198755 antibody OTTHUMP00000198756 antibody OTTHUMP00000198757 antibody OTTHUMP00000198758 antibody RAGP1_HUMAN antibody Ran 1 antibody RAN GTPase activating protein 1 antibody Ran GTPase-activating protein 1 antibody Ran1 antibody RANGAP 1 antibody RANGAP antibody RanGAP1 antibody SD antibody Segregation distorter homolog antibody Segregation distortion antibody

Abbreviation

RanGAP1, RANGAP1, KIAA1835, SD

Swiss Prot

P46060 Human, P46061 Mouse,

Cellular Locus

Cytoplasm. Cytoskeleton. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human RanGAP1 aa 1-50 / 587.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC, IP

Positive Control

HeLa cell lysate, A431 cell lysate, MCF7 cell lysate, SH-SY5Y cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, human testis tissue, mouse testis tissue, rat testis tissue, MCF7, NIH/3T3, PC-12.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100 ;IHC-P: 1:50-1:200 ;FC: 1:100 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 63 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes