PICK1 Recombinant Rabbit Monoclonal Antibody [JG30-80]

About this product

Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.

Specifications

Catalog number

ET7108-60

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

dJ1039K5 antibody MGC15204 antibody OTTHUMP00000028509 antibody PICK 1 antibody Pick1 antibody PICK1_HUMAN antibody PRKCA binding protein antibody PRKCA-binding protein antibody PRKCABP antibody Protein interacting with C kinase 1 antibody Protein interacting with PRKCA antibody Protein interacting with PRKCA 1 antibody Protein kinase C alpha binding protein antibody Protein kinase C-alpha-binding protein antibody Protein that interacts with C kinase 1 antibody

Abbreviation

PICK1, PRKCABP

Swiss Prot

Q9NRD5 Human

Cellular Locus

cytoskeleton, perinuclear region, membrane, postsynaptic density, synaptosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PICK1 aa 1-50 / 415.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, FC

Positive Control

SK-Br-3 cell lysate, 293 cell lysate, 293T.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

47 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes