STUB1 Recombinant Rabbit Monoclonal Antibody [JG38-22]

About this product

CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.

Specifications

Catalog number

ET7108-65

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antigen NY CO 7 antibody Antigen NY-CO-7 antibody C terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70 interacting protein antibody Carboxy terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70p interacting protein antibody CHIP antibody CHIP_HUMAN antibody CLL associated antigen KW 8 antibody CLL-associated antigen KW-8 antibody E3 ubiquitin protein ligase CHIP antibody E3 ubiquitin-protein ligase CHIP antibody Heat shock protein A binding protein 2 (c terminal) antibody HSPABP2 antibody NY CO 7 antibody PP1131 antibody SDCCAG7 antibody Serologically defined colon cancer antigen 7 antibody STIP1 homology and U Box containing protein 1 antibody STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody STIP1 homology and U box-containing protein 1 antibody STUB 1 antibody STUB1 antibody UBOX 1 antibody UBOX1 antibody

Abbreviation

STUB1, CHIP, PP1131

Swiss Prot

Q9UNE7 Human, Q9WUD1 Mouse,

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human STUB1 aa 10-59 / 303.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

HeLa cell lysate, HEK-293 cell lysate, human brain tissue lysate, human heart tissue, mouse heart tissue, rat heart tissue, 293T, LOVO, MCF-7, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes