Ube2N Recombinant Rabbit Monoclonal Antibody [JG38-68]

About this product

Ube2N, a member of the E2 Ubiquitin-conjugating enzyme family, completes the second step of ubiquitination reactions, essentially targeting proteins for proteasomic degradation. When proteins are modified with ubiquitin in an important cellular mechanism targeting abnormal or short lived proteins, ubiquitin, a short protein of 76 amino acids, attaches to a lysine residue resting on the target protein. Multiple cycles of ubiquitination create a polyubiquitin chain that the proteasome recognizes and subsequently triggers the ATP-dependent unfolding of the target protein. This allows protoeolytic degradation of the target protein. These degradation products are highly expressed in heart and skeletal muscles. Ube2N moderates the transcriptional activation of target genes, affects the progress of cell differentiation and aging, and also influences the DNA repair pathway, further adding to the survival of cells after DNA damage.

Specifications

Catalog number

ET7108-75

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Bendless like ubiquitin conjugating enzyme antibody Bendless-like ubiquitin-conjugating enzyme antibody BLU antibody EC 6.3.2.19 antibody Epididymis secretory protein Li 71 antibody HEL-S-71 antibody Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody MGC131857 antibody MGC8489 antibody UBC 13 antibody Ubc13 antibody UbCH ben antibody UbcH-ben antibody UbcH13 antibody UBCHBEN antibody Ube 2N antibody Ube2n antibody UBE2N_HUMAN antibody Ubiquitin carrier protein N antibody Ubiquitin conjugating enzyme E2 N antibody Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody Ubiquitin conjugating enzyme E2N antibody Ubiquitin protein ligase N antibody Ubiquitin-conjugating enzyme E2 N antibody Ubiquitin-protein ligase N antibody Yeast UBC13 homolog antibody

Abbreviation

UBE2N, BLU

Swiss Prot

P61088 Human, P61089 Mouse, Q9EQX9 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Ube2N aa 1-93 / 152.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

Daudi, SH-SY-5Y, mouse spleen tissue lysate, rat spleen tissue lysate, human colon tissue, human prostate cancer tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes