DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] — image 1 of 3

Product details

DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70]

Catalog number ET7108-76

Price for ET7108-76

Size / count 100 µL

About this product

Natural killer (NK) cells are regulated by stimulatory and inhibitory signals from a variety of receptors. Three main receptor families are responsible for NK cells recognition of MHC I molecules, including Ly-49, CD94/NKG2 and KIR (killer-cell inhibitory receptor). DAP12 is a phosphoprotein that is involved in the activation of NK cells. This protein interacts with membrane glycoproteins of the KIR family, resulting in cellular activation. DAP12 also binds to CD94/NKG2C, an activating NK cell receptor belonging to the C-type lectin superfamily. Additional proteins that bind to DAP12 include Ly-49D and Ly-49H, which associate with DAP12 in the plasma membrane. Phosphorylated DAP12 binds to ZAP-70 and Syk, suggesting that the activation pathway may be similar to that of the T and B cell antigen receptors.

Specifications

Catalog number: ET7108-76
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: DAP 12 antibody DAP12 antibody DNAX activation protein 12 antibody DNAX-activation protein 12 antibody KAR-associated protein antibody KARAP antibody Killer activating receptor associated protein antibody Killer-activating receptor-associated protein antibody PLOSL antibody TYOBP_HUMAN antibody TYRO protein tyrosine kinase binding protein antibody TYRO protein tyrosine kinase-binding protein antibody TYROBP antibody
Abbreviation: KAR-associated protein, TYROBP, DAP12, KARAP
Swiss Prot: O43914 Human
Cellular Locus: Membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human DAP12 aa 1-113 / 113.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: THP-1 cell lysates, human lung carcinoma tissue, K562.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 12 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70]?

The catalog number for DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] is ET7108-76.

What sizes are available for DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70]?

DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] is available in the following size(s): 100 µL.

Is DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] in stock?

DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DAP12 Recombinant Rabbit Monoclonal Antibody [JG38-70] used for?

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.