ORP150 Recombinant Rabbit Monoclonal Antibody [JG39-11]

About this product

ORP150, also known as HYOU1 (hypoxia upregulated 1), is a 999 amino acid protein that localizes to the lumen of the endoplasmic reticulum (ER) and is a member of the heat shock protein 70 (HSP 70) family. ORP150 is highly expressed in tissues that have well-developed ERs and a large number of secretory proteins (such as liver and pancreas). It is expressed at lower levels in kidney and brain, and plays an essential role in cytoprotective cellular responses to hypoxia (oxygen deprivation). Specifically, ORP150 participates in protein folding and secretion in the ER and functions to protect cells from hypoxia-induced apoptosis, thereby playing a crucial role in cell survival. ORP150 expression is upregulated in a variety of tumors, such as breast cancer, suggesting an important role in tumorigenesis. The gene encoding ORP150 has two translation initiation sites, resulting in a truncated transcript that lacks an ER signal peptide, but is thought to function as a housekeeping protein in the cytoplasm.

Specifications

Catalog number

ET7108-84

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

150 kDa oxygen regulated protein antibody 150 kDa oxygen-regulated protein antibody 170 kDa glucose regulated protein antibody 170 kDa glucose-regulated protein antibody DKFZp686N08236 antibody FLJ94899 antibody FLJ97572 antibody glucose regulated protein 170 antibody Grp 170 antibody GRP-170 antibody Grp170 antibody HSP 12A antibody HSP12A antibody Hyou1 antibody HYOU1_HUMAN antibody Hypoxia up regulated 1 antibody hypoxia up-regulated 1 precursor antibody Hypoxia up-regulated protein 1 antibody Hypoxia upregulated 1 antibody Orp 150 antibody ORP-150 antibody Orp150 antibody oxygen regulated protein (150kD) antibody

Abbreviation

ORP-150, GRP-170, HYOU1, GRP170, ORP150

Swiss Prot

Q9Y4L1 Human, Q9JKR6 Mouse

Cellular Locus

Endoplasmic reticulum.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human ORP150 aa 1-190 / 999.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

HepG2, mouse prostate tissue lysate, rat testis tissue, human liver cancer tissue, human small intestine tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:5,000-1:20,000;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

111 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes