CBFb Recombinant Rabbit Monoclonal Antibody [JG39-35]

About this product

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, a and b, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2a subunits, PEBP2aA, PEBP2aB and PEBP2aC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory b subunit, which facilitates DNA binding of the a subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2b is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2b/CBFB-SMMHC, that is associated with human acute myeloid leukemia.

Specifications

Catalog number

ET7108-87

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CBF b antibody CBF beta antibody CBF-beta antibody CBFB antibody CBFbeta antibody Core binding factor beta subunit antibody core binding factor subunit beta antibody Core-binding factor subunit beta antibody PEA 2 antibody PEA2 antibody PEA2 beta antibody PEA2-beta antibody PEA2beta antibody PEBB_HUMAN antibody PEBP 2B antibody PEBP2 beta antibody PEBP2-beta antibody PEBP2B antibody PEBP2beta antibody Polyomavirus enhancer binding protein 2 beta subunit antibody Polyomavirus enhancer-binding protein 2 beta subunit antibody SL3 3 enhancer factor 1 beta subunit antibody SL3 3 enhancer factor 1 subunit beta antibody SL3-3 enhancer factor 1 subunit beta antibody SL3/AKV core binding factor beta subunit antibody SL3/AKV core-binding factor beta subunit antibody

Abbreviation

CBF-beta, PEA2-beta, PEBP2-beta, CBFB

Swiss Prot

Q13951 Human, Q08024 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human CBFb aa 60-182 / 182.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Rat kidney tissue, human kidney tissue, SiHa, mouse lung tissue, mouse hippocampus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:50-1:400 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes