SUN2 Recombinant Rabbit Monoclonal Antibody [JG39-52]

About this product

SUN2 (sad1/unc-84 protein-like 2), also known as UNC84B (unc-84 homolog B), FRIGG, KIAA0668 or RAB5IP, is a 717 amino acid single-pass membrane protein that contains one SUN domain and localizes to the membrane of both the nucleus and the endosome. Widely expressed in a variety of tissues, including lung, muscle and heart, SUN2 interacts with Rab 5A and may play a role in homotypic endosome fusion. The gene encoding SUN2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

Specifications

Catalog number

ET7108-92

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FRIGG antibody KIAA0668 antibody nuclear envelope protein antibody Protein unc-84 homolog B antibody Rab5 interacting protein antibody RAB5IP antibody Sad1 and UNC84 domain containing 2 antibody Sad1 unc-84 domain protein 2 antibody Sad1 unc84 domain protein antibody Sad1/unc-84 protein-like 2 antibody Sad1/unc84 protein-like antibody SUN domain-containing protein 2 antibody UNC 84B antibody unc84 homolog B (C. elegans) antibody unc84 homolog B antibody unc84, C. elegans, homolog of, B antibody UNC84B antibody

Abbreviation

Rab5IP, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B

Swiss Prot

Q9UH99 Human, Q8BJS4 Mouse

Cellular Locus

Endosome. Nucleus inner membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human SUN2 aa 591-717 / 717.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IF-Cell, IF-Tissue

Positive Control

Saos-2 cell lysate, HeLa cell lysate, HepG2 cell lysate, A431 cell lysate, A431, human testis tissue, mouse testis tissue, rat testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:1,000 ;FC: 1:1,000 ;IF-Cell: 1:50-1:100 ;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 80 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes