Nectin 2 Recombinant Rabbit Monoclonal Antibody [JG39-64]

About this product

Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human nectin is identical to the poliovirus receptor-related protein (PRR) and has been identified as the α-herpesvirus entry mediator. Nectin constitutes a family consisting of at least Nectin 1, 2 and 3; each member has two or three splicing variants. Nectin 2, also designated PRR2/HveB, is ubquitously expressed, with the highest levels of expression in some human neuronal cell lines, fibroblastic cells, keratinocytes and primary activated T lymphocytes. Nectin 2 has two splicing variants, Nectin 2α (short form) and 2δ (long form). Both Nectin 2α and 2δ have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein afadin, through which it is linked to the Actin cytoskeleton. The extracellular regions of the splicing variants are identical, but their transmembrane regions and cytoplasmic regions are unique. Nectin 2 mediates the entry of three mutant herpes simplex virus type 1 (HSV-1) strains that do not use HveA as co-receptor, but not wildtype HSV-1 strains. Nectin 2 also mediates the entry of HSV-2 and pseudorabies virus, but not bovine herpes virus type 1. Nectin 2δ is tyrosine phosphorylated in response to cell-cell adhesion.

Specifications

Catalog number

ET7108-95

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CD 112 antibody CD112 antibody CD112 antigen antibody Herpes virus entry mediator B antibody Herpes virus entry protein B antibody Herpesvirus entry mediator B antibody Herpesvirus entry protein B antibody Hve B antibody HveB antibody Nectin-2 antibody Nectin2 antibody Poliovirus receptor like 2 antibody Poliovirus receptor related 2 (herpesvirus entry mediator B) antibody Poliovirus receptor related 2 antibody Poliovirus receptor related protein 2 antibody Poliovirus receptor-related protein 2 antibody PRR 2 antibody PRR2 antibody PVRL 2 antibody PVRL2 antibody PVRL2_HUMAN antibody PVRR 2 antibody PVRR2 antibody

Abbreviation

Herpesvirus entry mediator B, HveB, CD112, NECTIN2, HVEB, PRR2, PVRL2

Swiss Prot

Q92692 Human, P32507 Mouse, Q5FVC5 Rat

Cellular Locus

Cell membrane. Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Nectin 2 aa 370-538 / 538.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

K562 cell lysate, MCF-7 cell lysate, SKOV-3 cell lysate, MCF-7, LOVO, human liver carcinoma tissue, mouse testis tissue, rat testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2000 ;IF-Cell: 1:50 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes