Retinoid X Receptor alpha Recombinant Rabbit Monoclonal Antibody [JG99-38]

About this product

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Specifications

Catalog number

ET7108-99

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FLJ00280 antibody FLJ00318 antibody FLJ16020 antibody FLJ16733 antibody MGC102720 antibody NR2B1 antibody Nuclear receptor subfamily 2 group B member 1 antibody OTTHUMP00000022510 antibody Retinoic acid receptor RXR alpha antibody Retinoic acid receptor RXR-alpha antibody Retinoid X nuclear receptor alpha antibody Retinoid X receptor alpha antibody RXR alpha1 antibody Rxra antibody RXRA_HUMAN antibody RXRalpha1 antibody

Abbreviation

RXRA, NR2B1

Swiss Prot

P19793 Human, P28700 Mouse, Q05343 Rat

Cellular Locus

Mitochondrion, Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Immunogen

Recombinant protein corresponding to Human Retinoid X Receptor alpha aa 1-50 / 462.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

A549 cell lysate, MCF-7 cell lysate, A549, Hela, rat liver tissue, human esophagus tissue, human skin tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:400 ;IF-Cell: 1:50 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes