RACK1 Recombinant Rabbit Monoclonal Antibody [JG40-26]

About this product

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that may be involved in the activation-induced translocation of PKC. RACK1 (receptor for activated C kinase 1) is a 317 amino acid G protein b subunit-like protein that functions as a RACK and inhibits the activity of Src tyrosine kinases. In response to PKC activation, the intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII co-localize to the same sites. RACK1 is therefore thought to be a shuttling protein for PKC bII. A deficit in RACK1 may be associated with impaired PKC activation in the aging brain. The RACK1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome 5q35.3.

Specifications

Catalog number

ET7109-04

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cell proliferation-inducing gene 21 protein antibody GBLP_HUMAN antibody Gnb2-rs1 antibody Gnb2l1 antibody Guanine nucleotide binding protein (G protein) beta polypeptide 2 like 1 antibody Guanine nucleotide binding protein beta polypeptide 2 like 1 antibody Guanine nucleotide binding protein beta subunit 2 like 1 antibody Guanine nucleotide binding protein beta subunit like protein 12.3 antibody Guanine nucleotide binding protein subunit beta 2 like 1 antibody Guanine nucleotide binding protein subunit beta like protein 12.3 antibody Guanine nucleotide-binding protein subunit beta-2-like 1 antibody Guanine nucleotide-binding protein subunit beta-like protein 12.3 antibody H12.3 antibody HLC-7 antibody Human lung cancer oncogene 7 protein antibody lung cancer oncogene 7 antibody OTTHUMP00000223704 antibody OTTHUMP00000223870 antibody OTTHUMP00000223891 antibody OTTHUMP00000223893 antibody OTTHUMP00000223900 antibody OTTHUMP00000223902 antibody OTTHUMP00000223930 antibody OTTHUMP00000223931 antibody PIG21 antibody Proliferation inducing gene 21 antibody Protein homologous to chicken B complex protein guanine nucleotide binding antibody RACK1 antibody Receptor for activated C kinase 1 antibody Receptor for activated C kinase antibody Receptor of activated protein kinase C 1 antibody

Abbreviation

HLC-7, RACK1, GNB2L1

Swiss Prot

P63244 Human, P63245 Rat

Cellular Locus

Cytoplasm. Cell membrane. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human RACK1 aa 190-317 / 317.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

SH-SY5Y cell lysate, Daudi cell lysate, rat cerebellum tissue, rat liver tissue, human colon tissue, mouse skin tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes