TTC11/FIS1 Recombinant Rabbit Monoclonal Antibody [JE40-90]

About this product

Fis1 localizes to the outer mitochondrial membrane and, along with dynamin-related protein (Drp1), participates in mitochondrial fission. Fission and fusion mechanisms regulate mitochondrial morphology within the cell. Fission frequency is determined by the level of Fis1 molecules at the mitochondrial surface. Fis1 contains a C-terminal domain, which is required for mitochondrial localization, and an N-terminal domain, which is necessary for mitochondrial fission. Fragmentation of the mitochondrial network by Fis1 leads to cytochrome c release and apoptosis. The mitochondrial fission mechanisms may be involved in positively and negatively regulating apoptosis.

Specifications

Catalog number

ET7109-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2010003O14Rik antibody CGI 135 antibody CGI135 antibody FIS 1 antibody FIS1 antibody Fis1 homolog antibody FIS1, S. cerevisiae, homolog of antibody FIS1_HUMAN antibody Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) antibody Fission 1 (mitochondrial outer membrane) homolog (yeast) antibody Fission 1 (mitochondrial outer membrane) homolog antibody Fission 1 homolog antibody H NH0132A01.6 antibody hFis 1 antibody hFis1 antibody Mitochondrial fission 1 protein antibody mitochondrial fission molecule antibody Tetratricopeptide repeat domain 11 antibody Tetratricopeptide repeat protein 11 antibody TPR repeat protein 11 antibody TTC 11 antibody

Abbreviation

hFis1, TPR repeat protein 11, FIS1, TTC11

Swiss Prot

Q9Y3D6 Human, Q9CQ92 Mouse, P84817 Rat

Cellular Locus

Peroxisome. Mitochondrion.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human TTC11 aa 1-125 / 152.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IF-Tissue

Positive Control

Mouse spleen tissue lysate, mouse brain tissue lysate, rat spleen tissue lysate, rat brain tissue lysate, MCF-7, SH-SY-5Y, SK-Br-3, human kidney tissue, human small intestine tissue, human uterus tissue, mouse brain tissue, mouse colon tissue, rat brain tissue, rat colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:1,000 ;IF-Tissue: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes