PPP1CB Recombinant Rabbit Monoclonal Antibody [JE45-08]

About this product

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP1 family is comprised of subfamily members PP1α, PP1β and PP1γ, which are MgATP-dependent enzymes. PP1 inactivity is maintained through its association with the inhibitory protein NIPP-1 (nuclear inhibitor of PP1). Phosphorylation of NIPP-1 by cAMP-PK or casein kinase II results in the release of active PP1.

Specifications

Catalog number

ET7109-40

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

MGC3672 antibody PP 1B antibody PP-1B antibody PP1B antibody PP1B_HUMAN antibody PP1beta antibody PPP1CB antibody PPP1CD antibody Protein phosphatase 1 beta antibody Protein phosphatase 1 catalytic subunit beta isoform antibody Protein phosphatase 1 delta antibody Protein phosphatase 1, catalytic subunit, beta isozyme antibody Protein phosphatase 1, catalytic subunit, delta isoform antibody Serine threonine protein phosphatase PP1 beta catalytic subunit antibody Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody

Abbreviation

PP-1B, PPP1CD, PPP1CB

Swiss Prot

P62140 Human, P62141 Mouse, P62142 Rat

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PPP1CB aa 278-327 / 327.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, IHC-P

Positive Control

Mouse skeletal muscle tissue, rat brain tissue, A431, SH-SY-5Y, SiHa, 293, Hela, PC-3M, HepG2, A549, human appendix tissue, human esophagus tissue, mouse colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:10,000 ;IP: 1:50 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes