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![Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81aad/imageurl/et7109-42.webp)
Product details
Catalog number ET7109-42
Price for ET7109-42
Size / count 100 µL
Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs. The primary function of alpha-actinin-2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton et al. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin-2 also functions in docking signalling molecules at Z-discs, and additional studies have also implicated alpha-actinin-2 in the binding of cardiac ion channels, Kv1.5 in particular.
The catalog number for Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22] is ET7109-42.
Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22] is available in the following size(s): 100 µL.
Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22] is currently made to order / not held in immediate stock. Contact us for lead time.
Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs. The primary function of alpha-actinin-2 is to c
Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.
A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.
Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.
