ATP2A1/SERCA1 Recombinant Rabbit Monoclonal Antibody [JE45-75]

About this product

This gene encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form the catalytic site, and the actuator domain, which is involved in the transmission of major conformational changes. It seems that, in addition to the calcium-transporting properties, SERCA1 generates heat in some adipocytes and can improve cold tolerance in some wood frogs.

Specifications

Catalog number

ET7109-43

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

fast twitch skeletal muscle isoform antibody AT2A1_HUMAN antibody ATP2A antibody ATP2A1 antibody ATPase Ca++ transporting cardiac muscle fast twitch 1 antibody ATPase Ca++ transporting fast twitch 1 antibody ATPase, Ca (2+)-transporting fast twitch 1 antibody Calcium pump 1 antibody Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform antibody Calcium-transporting ATPase sarcoplasmic reticulum type antibody EC 3.6.3.8 antibody Endoplasmic reticulum class 1/2 Ca (2+) ATPase antibody Fast skeletal muscle SR calcium ATPase antibody OTTHUMP00000162561 antibody OTTHUMP00000162562 antibody Sarcoendoplasmic reticulum calcium ATPase antibody Sarcoplasmic reticulum Ca (2+)-ATPase 1 antibody Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 antibody SERCA 1 antibody SERCA1 antibody SERCA1 truncated isoform, included antibody SR Ca (2+) ATPase 1 antibody SR Ca (2+)-ATPase 1 antibody

Abbreviation

SERCA1, SR Ca (2+)-ATPase 1, ATP2A1

Swiss Prot

O14983 Human

Cellular Locus

Endoplasmic reticulum membrane, Sarcoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human SERCA1 ATPase aa 1-50 / 1,001.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP, IHC-P

Positive Control

Human fetal skeletal muscle tissue lysate, human fetal skeletal muscle tissue, human striated muscle tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:1,000 ;IP: 1:10-1:50 ;IHC-P:1:50-1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 110 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes