GCDFP 15 Recombinant Rabbit Monoclonal Antibody [JE48-53]

About this product

Prolactin-inducible protein also known as gross cystic disease fluid protein 15 (GCDFP-15), extra-parotid glycoprotein (EP-GP), gp17 seminal actin-binding protein (SABP) or BRST2 is a protein that in humans is encoded by the PIP gene. It is upregulated by prolactin and androgens and downregulated by estrogen. The protein has a physiological function in regulation of water transport mainly in apocrine glands in the axilla, vulva, eyelid and ear canal, serous cells of the submandibular salivary gland, serous cells of the submucosal glands of the bronchi, and accessory lacrimal glands as well as cutaneous eccrine glands. It is also found in amniotic fluid and seminal fluid. PIP has the ability to bind immunoglobulin G (IgG), IgG-Fc, CD4-T cell receptor suggesting a wide range of immunological functions. PIP also binds to AZGP1. PIP exerts aspartyl proteinase activity able to cleave fibronectin. PIP can bind different species of bacteria showing highest affinity to streptococci thus playing a role in non-immune defense of the body against pathogenic bacterial strains. Mitogenic effect of PIP was observed on both normal and malignant breast epithelial cells.

Specifications

Catalog number

ET7109-80

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

BRST-2 antibody BRST2 antibody GCDFP-15 antibody GCDGP15 antibody gp17 antibody GPIP4 antibody Gross cystic disease fluid protein 15 antibody PIP antibody PIP_HUMAN antibody Prolactin induced protein antibody Prolactin inducible protein precursor antibody Prolactin-induced protein antibody Prolactin-inducible protein antibody SABP antibody Secretory actin binding protein antibody Secretory actin-binding protein antibody

Abbreviation

GCDFP-15, SABP, PIP, GCDFP15, GPIP4

Swiss Prot

P12273 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human GCDFP 15 aa 97-146 / 146.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Hela, human seminal vesicle tissue, human breast tissue, human breast cancer tissue.

Concentration

1 mg/mL

Dilution

WB:1:500;IF-Cell: 1:50;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 17 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes