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![PSMD14 Recombinant Rabbit Monoclonal Antibody [JE48-88] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c90061270361ea828fd/imageurl/et7109-85.webp)
Product details
Catalog number ET7109-85
Price for ET7109-85
Size / count 100 µL
As the degradation machinery that is responsible for ~70% of intracellular proteolysis, the proteasome complex (26S proteasome) plays critical roles in maintaining the homeostasis of the cellular proteome. Misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in addition, some key regulatory proteins fulfil their biological functions via selective degradation; furthermore, proteins are digested into peptides for MHC class I antigen presentation. To meet such complicated demands in biological processes via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a controlled fashion. Thus, the 19S regulatory particle has a series of important capabilities to address these functional challenges. To recognize proteins as designated substrates, the 19S complex has subunits that are capable of recognizing proteins with a special degradative tag, ubiquitination. It also has subunits that can bind to nucleotides (e.g., ATPs) in order to facilitate the association between the 19S and 20S particles, as well as to cause conformational changes to the alpha subunit C-terminals that form the substate entrance of the 20S complex. Rpn11 drives metalloprotease activity to hydrolyze the ubiquitin molecules from the poly-ubiquitin chain before protein substrates are unfolded and degraded.
The catalog number for PSMD14 Recombinant Rabbit Monoclonal Antibody [JE48-88] is ET7109-85.
PSMD14 Recombinant Rabbit Monoclonal Antibody [JE48-88] is available in the following size(s): 100 µL.
PSMD14 Recombinant Rabbit Monoclonal Antibody [JE48-88] is currently made to order / not held in immediate stock. Contact us for lead time.
As the degradation machinery that is responsible for ~70% of intracellular proteolysis, the proteasome complex (26S proteasome) plays critical roles in maintaining the homeostasis of the cellular proteome. Misfolded proteins and damaged protein need to be continuously removed to recycle amino acids
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.
Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.
