PKA R2 Recombinant Rabbit Monoclonal Antibody [JE49-49]

About this product

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent Protein Kinase, more commonly called Protein Kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins (AKAPs) and determine the subcellular localization of PKA. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Specifications

Catalog number

ET7109-92

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alternative names cAMP dependent protein kinase regulatory subunit alpha 2 antibody cAMP dependent protein kinase regulatory subunit RII alpha antibody cAMP dependent protein kinase type II alpha regulatory chain antibody cAMP dependent protein kinase type II alpha regulatory subunit antibody cAMP-dependent protein kinase type II-alpha regulatory subunit antibody KAP2 antibody KAP2_HUMAN antibody MGC3606 antibody PKR 2 antibody PKR2 antibody PRKA R2 antibody PRKAR 2 antibody PRKAR2 antibody PRKAR2A antibody Protein kinase A RII alpha subunit antibody Protein kinase cAMP dependent regulatory type II alpha antibody

Abbreviation

PRKAR2A, PKR2, PRKAR2

Swiss Prot

P13861 Human

Cellular Locus

Cell membrane, Cytoplasm, Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human PKA R2 aa 272-404 / 404.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

Hela cell lysates, human liver cancer tissue, human skin tissue, human breast tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;IP:1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes