EWSR1/EWS Recombinant Rabbit Monoclonal Antibody [JE49-57]

About this product

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family. The q22.2 region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several other chromosomes which encode various transcription factors, see and the FET protein family. The expression of a chimeric protein with the EWS transactivation domain fused to the DNA binding region of a transcription factor generates a powerful oncogenic protein causing Ewing sarcoma and other members of the Ewing family of tumors. These translocations can occur due to chromoplexy, a burst of complex chromosomal rearrangements seen in cancer cells. The normal EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated to amyotrophic lateral sclerosis.

Specifications

Catalog number

ET7109-94

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

bK984G1.4 antibody bK984G1.4 Ewing sarcoma breakpoint region 1 protein antibody Ewing sarcoma breakpoint region 1 antibody Ewing sarcoma breakpoint region 1 protein antibody Ewings sarcoma EWS Fli1 type 1 oncogene antibody EWS antibody EWS oncogene antibody EWS RNA binding protein 1 antibody EWS_HUMAN antibody EWSR 1 antibody Ewsr1 antibody EWSR1 protein antibody RNA binding protein EWS antibody RNA-binding protein EWS antibody

Abbreviation

EWSR1, EWS

Swiss Prot

Q01844 Human, Q61545 Mouse,

Cellular Locus

Cytoplasm. Plasma membrane. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human EWSR1 / EWS aa 1-229 / 656.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

K562 cell lysate, A431 cell lysate, A431, SK-Br-3, rat testis tissue, human thyroid gland tissue, human skin tissue, human breast cancer tissue, human pancreas tissue, mouse kidney tissue, mouse heart tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2000;IF-Cell:1:50-1:200;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes