ABAT / GABA-T Recombinant Rabbit Monoclonal Antibody [JE50-16]

About this product

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Specifications

Catalog number

ET7110-01

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

(S) 3 amino 2 methylpropionate transaminase antibody (S)-3-amino-2-methylpropionate transaminase antibody 4 aminobutyrate aminotransferase antibody 4 aminobutyrate aminotransferase, mitochondrial antibody 4-aminobutyrate aminotransferase antibody ABAT antibody FLJ17813 antibody FLJ30272 antibody GABA aminotransferase antibody GABA AT antibody GABA T antibody GABA transaminase antibody GABA transferase antibody GABA-AT antibody GABA-T antibody GABAT antibody GABT_HUMAN antibody Gamma amino N butyrate transaminase antibody Gamma-amino-N-butyrate transaminase antibody hCG1984265 antibody L AIBAT antibody L-AIBAT antibody LAIBAT antibody mitochondrial antibody NPD009 antibody

Abbreviation

GABA-AT, GABA transaminase, GABA-T, ABAT, GABAT

Swiss Prot

P80404 Human, P61922 Mouse, P50554 Rat

Cellular Locus

Mitochondrion.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human ABAT / GABA-T aa 1-124 / 500.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

HepG2 cell lysate, Neuro-2a cell lysate, human liver tissue lysate, rat liver tissue lysate, human liver cancer tissue, human placenta tissue, mouse kidney tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000 ;IP:1:50 ;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 56 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes