BCL2L12 Recombinant Rabbit Monoclonal Antibody [JE51-66]

About this product

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene. The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.

Specifications

Catalog number

ET7110-02

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

B2L12_HUMAN antibody BCL 2 like 12 (proline rich) antibody BCL 2 like 12 antibody BCL 2 like 12 isoform 1 antibody Bcl 2 like 12 protein antibody Bcl 2 related proline rich protein antibody Bcl-2-like protein 12 antibody Bcl-2-related proline-rich protein antibody BCL2 like 12 (proline rich) antibody BCL2 like 12 antibody BCL2 like 12 isoform 1 antibody Bcl2 like 12 protein antibody Bcl2 related proline rich protein antibody Bcl2-L-12 antibody BCL2L12 antibody BPR antibody MGC120313 antibody MGC120314 antibody MGC120315 antibody

Abbreviation

BCL2L12

Swiss Prot

Q9HB09 Human

Cellular Locus

Nucleus, membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human BCL2L12 aa 180-320 / 334.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

MCF-7 cell lysate, PC-3M cell lysate, A431, SW620, human lung carcinoma tissue, human gastric carcinoma tissue, human colon carcinoma tissue, human testis tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000;IF-Cell:1:50-1:100;IHC-P:1:200-1:1000;FC:1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes