NeuroD2 Recombinant Rabbit Monoclonal Antibody [JE50-57]

About this product

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).

Specifications

Catalog number

ET7110-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

bHLHa1 antibody class A basic helix loop helix protein 1 antibody Class A basic helix-loop-helix protein 1 antibody NDF2_HUMAN antibody NDR2 antibody NDRF antibody neuroD related factor antibody NeuroD-related factor antibody NeuroD2 antibody neurogenic basic helix loop helix protein antibody neurogenic differentiation 2 antibody Neurogenic differentiation factor 2 antibody neuronal differentiation 2 antibody

Abbreviation

NEUROD2

Swiss Prot

Q15784 Human, Q62414 Mouse, Q63689 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Mouse, Rat, Human

Immunogen

Recombinant protein within Human NeuroD2 aa 260-382 / 382.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P, WB

Positive Control

Rat brain tissue, mouse brain tissue, mouse hippocampus tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:200-1:1,000 ;WB: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes