Timeless Recombinant Rabbit Monoclonal Antibody [JE51-39]

About this product

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock. Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. TIMELESS promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress by promoting DNA repair. In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity).

Specifications

Catalog number

ET7110-23

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FLJ12640 antibody FLJ20714 antibody hTIM antibody Protein timeless homolog antibody TIM antibody TIM_HUMAN antibody TIM1 antibody Timeless antibody timeless circadian clock 1 antibody timeless circadian clock antibody timeless homolog antibody TIMELESS1 antibody Tof1 homolog antibody

Abbreviation

TIMELESS

Swiss Prot

Q9UNS1 Human

Cellular Locus

Chromosome, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Timeless aa 1,018-1,208 / 1,208.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysates, 293T cell lysates, Daudi cell lysates, human tonsil tissue, human colon carcinoma tissue, human gastric carcinoma tissue, human small intestine tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 139 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes