SLC22A3 Recombinant Rabbit Monoclonal Antibody [JE53-70]

About this product

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. OCT3 is widely distributed in brain tissue. It is not yet completely clear whether its location is primarily neuronal or glial. Organic cation transporter 3 is a polyspecific transporter whose transport is independent of sodium. Known substrates for transport include: histamine, serotonin, norepinephrine, dopamine and MPP+. Capacity for transport and affinity for these substrates may vary between rat and human isoforms however. ransport activity of OCT3 is inhibited by recreational and pharmaceutical drugs, including MDMA, phencyclidine (PCP), MK-801, amphetamine, methamphetamine and cocaine. Transport is also inhibited by the chemical decynium-22 and physiological concentrations of corticosterone and cortisol. Ki values for decynium-22 and corticosterone inhibition of OCT3 transport are respectively 10 and 100 times lower than Ki values of OCT1 and OCT2.

Specifications

Catalog number

ET7110-35

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

EMT antibody EMT organic cation transporter 3 antibody EMTH antibody Extraneuronal monoamine transporter antibody OCT 3 antibody OCT3 antibody Orct 3 antibody Orct3 antibody Organic cation transporter 3 antibody S22A3_HUMAN antibody SLC22 A3 antibody SLC22A 3 antibody Slc22a3 antibody Solute carrier family 22 (extraneuronal monoamine transporter) member 3 antibody Solute carrier family 22 (organic cation transporter) member 3 antibody Solute carrier family 22 member 3 antibody

Abbreviation

SLC22A3

Swiss Prot

O75751 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human SLC22A3 aa 281-470 / 556.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Human placenta tissue lysates, human colon carcinoma tissue, A549.

Concentration

1 mg/mL

Dilution

WB:1:1000-1:5,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 61 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes