SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] — image 1 of 2

Product details

SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04]

Catalog number ET7110-49

Price for ET7110-49

Size / count 100 µL

About this product

The silent information regulator (SIR2) family of genes are highly-conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 is highly expressed in heart, brain and skeletal muscle, with low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lys 382.

Specifications

Catalog number: ET7110-49
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 75SirT1 antibody hSIR2 antibody hSIRT1 antibody HST2 antibody HST2, S. cerevisiae, homolog of antibody NAD dependent deacetylase sirtuin 1 antibody NAD dependent protein deacetylase sirtuin 1 antibody NAD-dependent deacetylase sirtuin-1 antibody OTTHUMP00000198111 antibody OTTHUMP00000198112 antibody Regulatory protein SIR2 homolog 1 antibody SIR1_HUMAN antibody SIR2 antibody SIR2 like 1 antibody SIR2 like protein 1 antibody SIR2, S.cerevisiae, homolog-like 1 antibody SIR2-like protein 1 antibody SIR2ALPHA antibody SIR2L1 antibody Sirt1 antibody SirtT1 75 kDa fragment antibody Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) antibody Sirtuin 1 antibody Sirtuin type 1 antibody
Abbreviation: SIRT1
Swiss Prot: Q96EB6 Human
Cellular Locus: Cytoplasm, Mitochondrion, Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within C terminal human SIRT1.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: Jurkat cell lysate, HepG2 cell lysate, Hela cell lysate, Hela.
Concentration: 1 mg/mL
Dilution: WB:1:1000-1:2,000 ;IF-Cell:1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 82 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04]?

The catalog number for SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] is ET7110-49.

What sizes are available for SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04]?

SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] is available in the following size(s): 100 µL.

Is SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] in stock?

SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SIRT1 Recombinant Rabbit Monoclonal Antibody [JE11-04] used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.