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![MGMT Recombinant Rabbit Monoclonal Antibody [JE31-37] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea8245f/imageurl/et7110-52.webp)
Product details
Catalog number ET7110-52
Price for ET7110-52
Size / count 100 µL
MGMT is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. O6-methylguanine DNA methyltransferase is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents. The two bacterial isozymes are Ada and Ogt. Although alkylating mutagens preferentially modify the guanine base at the N7 position, O6-alkyl-guanine is a major carcinogenic lesion in DNA. This DNA adduct is removed by the repair protein O6-alkylguanine DNA alkyltransferase through an SN2 mechanism. This protein is not a true enzyme since it removes the alkyl group from the lesion in a stoichiometric reaction and the active enzyme is not regenerated after it is alkylated (referred to as a suicide enzyme). The methyl-acceptor residue in the protein is a cysteine.
The catalog number for MGMT Recombinant Rabbit Monoclonal Antibody [JE31-37] is ET7110-52.
MGMT Recombinant Rabbit Monoclonal Antibody [JE31-37] is available in the following size(s): 100 µL.
MGMT Recombinant Rabbit Monoclonal Antibody [JE31-37] is currently made to order / not held in immediate stock. Contact us for lead time.
MGMT is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. O6-methylguanine DNA methyltransferase is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors dur
Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.
Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.
Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.
