Beta glucuronidase Recombinant Rabbit Monoclonal Antibody [JE54-34]

About this product

Beta-glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates.Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate. Human β-glucuronidase is located in the lysosome. n the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. Beta-glucuronidase is also present in breast milk, which contributes to neonatal jaundice. The protein is encoded by the GUSB gene in humans and by the uidA gene in bacteria. Deficiencies in β-glucuronidase result in the autosomal recessive inherited metabolic disease known as Sly syndrome or Mucopolysaccharidosis VII. A deficiency in this enzyme results in the build-up of non-hydrolyzed mucopolysaccharides in the patient. This disease can be extremely debilitating for the patient or can result in hydrops fetalis prior to birth.

Specifications

Catalog number

ET7110-66

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Ac2-223 antibody asd antibody Beta G1 antibody Beta glucuronidase antibody Beta-G1 antibody Beta-glucuronidase antibody BG antibody BGLR antibody BGLR_HUMAN antibody FLJ39445 antibody Glucuronidase beta antibody Gur antibody Gus antibody Gus-r antibody Gus-s antibody Gus-t antibody Gus-u antibody GUSB antibody Gut antibody MPS7 antibody

Abbreviation

GUSB

Swiss Prot

P08236 Human

Cellular Locus

Lysosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human beta glucuronidase aa 1-160 / 651.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

U937 cell lysate, human lung tissue lysate, THP-1 cell lysates, human prostate carcinoma tissue, human kidney tissue, THP-1.

Concentration

1 mg/mL

Dilution

WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

75 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes