BAT3 Recombinant Rabbit Monoclonal Antibody [JE54-90]

About this product

ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins.

Specifications

Catalog number

ET7110-88

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2410045D21Rik antibody AA408914 antibody BAG 6 antibody BAG family molecular chaperone regulator 6 antibody BAG-6 antibody BAG6 antibody BAG6_HUMAN antibody BAT 3 antibody BAT3 antibody BCL2-associated athanogene 6 antibody D17H6S52E antibody D6S52E antibody G3 antibody HLA B associated transcript 3 antibody HLA-B associated transcript 3 antibody HLA-B associated transcript-3 antibody HLA-B-associated transcript 3 antibody large proline rich protein BAG6 antibody Large proline rich protein BAT3 antibody Large proline-rich protein BAG6 antibody large proline-rich protein BAT3 antibody Protein G3 antibody Protein Scythe antibody Scythe antibody Scythe, homolog of Xenopus antibody

Abbreviation

BAG6

Swiss Prot

P46379 Human, Q9Z1R2 Mouse, Q6MG49 Rat

Cellular Locus

Extracellular exosome, cytosol, nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human BAT3 aa 1,083-1,132 / 1,132.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Rat testis tissue lysate, 293 cell lysate, HepG2 cell lysate, rat brain tissue lysate, mouse testis tissue lysate, mouse hippocampus tissue lysate, THP-1 cell lysate, A549, HepG2, rat testis tissue, human lung tissue, human lung carcinoma tissue,SW620.

Concentration

1 mg/mL

Dilution

WB:1:1,000-1:2,000 ;IF-Cell:1:50-1:100 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 119 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes