Arg2 Recombinant Rabbit Monoclonal Antibody [JE54-97]

About this product

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism. In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal.

Specifications

Catalog number

ET7110-91

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ARG2 antibody ARGI2_HUMAN antibody Arginase II mitochondrial antibody Arginase type II antibody Arginase-2 antibody arginase-2, mitochondrial antibody Kidney arginase antibody Kidney type arginase antibody Kidney-type arginase antibody L arginine amidinohydrolase antibody L arginine ureahydrolase antibody mitochondrial antibody Non hepatic arginase antibody Non-hepatic arginase antibody Nonhepatic arginase antibody Type II arginase antibody

Abbreviation

ARG2

Swiss Prot

P78540 Human

Cellular Locus

Mitochondrion.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Arg2 aa 305-354 / 354.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

A549 cell lysate, Human small intestine tissue lysate, Human kidney tissue lysate, K562 cell lysate, human liver tissue, human prostate carcinoma tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000 ;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes