LMAN1 Recombinant Rabbit Monoclonal Antibody [JE55-19]

About this product

The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. MCFD2 is the second gene that leads to combined deficiency of factor V-factor VIII. ERGIC-53 and MCFD2 form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the ERGIC and then the Golgi, as illustrated here.

Specifications

Catalog number

ET7110-98

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Endoplasmic reticulum golgi intermediate compartment protein 53 antibody ER-Golgi intermediate compartment 53 kDa protein antibody ERGIC-53 antibody ERGIC53 antibody ERGIC53 like protein antibody F5F8D antibody FMFD1 antibody Gp58 antibody Intracellular mannose specific lectin antibody Intracellular mannose-specific lectin MR60 antibody Lectin mannose binding 1 antibody Lectin mannose-binding 1 antibody Lman1 antibody LMAN1 like protein antibody LMAN1_HUMAN antibody MCFD1 antibody MR60 antibody Protein ERGIC-53 antibody

Abbreviation

LMAN1

Swiss Prot

P49257 Human, Q9D0F3 Mouse, Q62902 Rat

Cellular Locus

Golgi apparatus membrane, endoplasmic reticulum membrane, endoplasmic reticulum-golgi intermediate compartment membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human LMAN1 aa 281-405 / 510.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

NIH/3T3 cell lysate, human placenta tissue lysate, HUVEC cell lysate, rat brain tissue, mouse kidney tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:1,000 ;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes