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![SerpinB3 Recombinant Rabbit Monoclonal Antibody [JE55-93] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c90061270361ea828fe/imageurl/et7111-21.webp)
Product details
Catalog number ET7111-21
Price for ET7111-21
Size / count 100 µL
SCCA1 Antibody is a high quality monoclonal SCCA1 antibody (also designated SCCA1 antibody) suitable for the detection of the SCCA1 protein of human origin. SCCA1 Antibody is available as both the non-conjugated anti-SCCA1 antibody form, as well as multiple conjugated forms of anti-SCCA1 antibody, including agarose, PE, FITC and multiple Alexa Fluor® conjugates. Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
The catalog number for SerpinB3 Recombinant Rabbit Monoclonal Antibody [JE55-93] is ET7111-21.
SerpinB3 Recombinant Rabbit Monoclonal Antibody [JE55-93] is available in the following size(s): 100 µL.
SerpinB3 Recombinant Rabbit Monoclonal Antibody [JE55-93] is currently made to order / not held in immediate stock. Contact us for lead time.
SCCA1 Antibody is a high quality monoclonal SCCA1 antibody (also designated SCCA1 antibody) suitable for the detection of the SCCA1 protein of human origin. SCCA1 Antibody is available as both the non-conjugated anti-SCCA1 antibody form, as well as multiple conjugated forms of anti-SCCA1 antibody, i
Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.
Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.
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