MBD2 Recombinant Rabbit Monoclonal Antibody [JE57-73]

About this product

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

Catalog number

ET7111-40

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Demethylase antibody DMTase antibody MBD 2 antibody Mbd2 antibody MBD2_HUMAN antibody MBD2a antibody Methyl CpG binding domain protein 2 antibody Methyl CpG binding protein MBD2 antibody Methyl-CpG-binding domain protein 2 antibody Methyl-CpG-binding protein MBD2 antibody NY CO 41 antibody

Abbreviation

MBD2

Swiss Prot

Q9UBB5 Human, Q9Z2E1 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human MBD2 aa 50-200.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Raji cell lysates, Daudi cell lysate, mouse kidney tissue, human lung carcinoma tissue, human breast carcinoma tissue, human kidney tissue, rat lung tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes