hNaa50p Rabbit Polyclonal Antibody

About this product

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine . Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position . Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins . Autoacetylates in vivo . The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo . Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides . Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 .

Specifications

Catalog number

HA500001

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

MAK3 antibody FLJ13194 antibody hNAT5 antibody hSAN antibody Mak3 homolog (S. cerevisiae) antibody Mak3 homolog antibody N-acetyltransferase 13 (GCN5-related) antibody N-acetyltransferase 13 antibody N-acetyltransferase 5 antibody N-acetyltransferase san homolog antibody N-alpha-acetyltransferase 50 antibody N-alpha-acetyltransferase 50, NatE catalytic subunit antibody Naa50 antibody NAA50_HUMAN antibody NAT 5 antibody NAT13 antibody NAT5 antibody NatE catalytic subunit antibody San antibody

Abbreviation

N-alpha-acetyltransferase 50Curated hNaa50p2 N-acetyltransferase 13 N-acetyltransferase 51 hNAT51 N-acetyltransferase san homolog1 hSAN1 N-epsilon-acetyltransferase 50Curated NatE catalytic subunit

Swiss Prot

Q9GZZ1 Human, Q6PGB6 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide within human hNaa50p aa 100-169.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

K562 cell lysates, rat lung tissue, human spleen tissue, mouse brain tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IHC-P: 1:100-1:400;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

19 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No