PSMA7 Rabbit Polyclonal Antibody

About this product

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Specifications

Catalog number

HA500004

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C6 antibody HSPC antibody MGC3755 antibody OTTHUMP00000031449 antibody OTTHUMP00000031450 antibody OTTHUMP00000031453 antibody Proteasome (prosome macropain) subunit alpha type 7 antibody Proteasome alpha 7 subunit antibody Proteasome subunit alpha 4 antibody Proteasome subunit alpha type 7 antibody Proteasome subunit alpha type-7 antibody Proteasome subunit RC6 1 antibody Proteasome subunit RC6-1 antibody Proteasome subunit XAPC7 antibody PSA7_HUMAN antibody PSMA 7 antibody PSMA7 antibody RC6 1 antibody XAPC7 antibody

Abbreviation

Proteasome subunit alpha type-7 Proteasome subunit RC6-1 Proteasome subunit XAPC7 PSMA7 HSPC

Swiss Prot

O14818 Human, Q9Z2U0 Mouse, P48004 Rat

Cellular Locus

Cytoplasm, Nucleus, Proteasome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human PSMA7 aa 50-248.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

SKBR-3 cell lysate, HepG2 cell lysate, Hela cell lysate, mouse liver tissue lysate, mouse lung tissue lysate, human liver carcinoma tissue, human pancreas tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:100-1:500;FC: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

28 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No