Dopamine Transporter Rabbit Polyclonal Antibody

About this product

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses, although there may be an exception in the prefrontal cortex, where evidence points to a possibly larger role of the norepinephrine transporter.DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, alcoholism, and substance use disorder. The gene that encodes the DAT protein is located on human chromosome 5, consists of 15 coding exons, and is roughly 64 kbp long. Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism, known as a VNTR, in the DAT gene (DAT1), which influences the amount of protein expressed.

Specifications

Catalog number

HA500007

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

DA transporter antibody DAT 1 antibody DAT antibody DAT1 antibody Dopamine transporter 1 antibody Dopamine transporter antibody PKDYS antibody SC6A3_HUMAN antibody SLC6A3 antibody Sodium dependent dopamine transporter antibody Sodium-dependent dopamine transporter antibody Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody Solute carrier family 6 (neurotransmitter transporter), member 3 antibody Solute carrier family 6 member 3 antibody Variable number tandem repeat (VNTR) antibody

Abbreviation

Sodium-dependent dopamine transporter DA transporter DAT Solute carrier family 6 member 3

Swiss Prot

Q01959 Human, Q61327 Mouse, P23977 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Dopamine Transporter aa 570-620.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

Mouse brian tissue lysates, rat brain tissue, mouse brain tissue, SKOV-3, F9.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:100-1:500;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No