GKAP Rabbit Polyclonal Antibody

About this product

The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins and to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been directly linked to a variety of psychological and neurological disorders. In this review we focus on the direct and indirect role of DLGAP family on schizophrenia as well as other brain diseases.

Specifications

Catalog number

HA500018

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

4933422O14Rik antibody 9630002F18 antibody AI845682 antibody AI848168 antibody BB075781 antibody D17Bwg0511e antibody DAP 1 ALPHA antibody DAP 1 antibody DAP 1 BETA antibody DAP-1 antibody DAP-1-ALPHA antibody DAP-1-BETA antibody DAP1 antibody Discs large (Drosophila) homolog associated protein 1 antibody Discs large homolog associated protein 1 antibody Disks large associated protein 1 antibody Disks large associated protein 1, alpha isoform, included antibody Disks large associated protein 1, beta isoform, included antibody Disks large-associated protein 1 antibody DLGAP 1 antibody Dlgap1 antibody DLGP1_HUMAN antibody GKAP antibody GKAP/SAPAP antibody GKPA/SAPAP antibody Guanylate kinase associated protein antibody Guanylate kinase-associated protein antibody hGKAP antibody KIAA4162 antibody MGC88156 antibody mKIAA4162 antibody PSD 95/SAP90 binding protein 1 antibody PSD-95/SAP90-binding protein 1 antibody SAP90/PSD 95 associated protein 1 antibody SAP90/PSD-95-associated protein 1 antibody SAPAP 1 antibody SAPAP1 antibody

Abbreviation

Disks large-associated protein 1 DAP-1 Guanylate kinase-associated protein hGKAP PSD-95/SAP90-binding protein 1 SAP90/PSD-95-associated protein 1 SAPAP1

Swiss Prot

O14490 Human, Q9D415 Mouse, P97836 Rat

Cellular Locus

Cell junction, Cell membrane, Membrane, Synapse.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human GKAP aa 380-430.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Human brain tissue cell lysates, PC-12, N2A, SHG-44, rat testis tissue, rat brain tissue, mouse testis tissue, mouse brain tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,1,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa-109 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No