cGAS Rabbit Polyclonal Antibody — image 1 of 3

Product details

cGAS Rabbit Polyclonal Antibody

Catalog number HA500023

Price for HA500023

Size / count 100 µL

About this product

cGAS Antibody (C-1) is a high quality monoclonal cGAS antibody (also designated cGAS antibody) suitable for the detection of the cGAS protein of human origin. cGAS Antibody (C-1) is available as the non-conjugated anti-cGAS antibody. The presence of foreign DNA in the cytoplasm induces an antiviral host immune response. DNA in the cytoplasm triggers the production of interferons by activating and synthesis of second messenger cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP). cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Specifications

Catalog number: HA500023
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: C6orf150 antibody cGAMP synthase antibody cGAS antibody CGAS_HUMAN antibody cGMP Synthase antibody Chromosome 6 open reading frame 150 antibody Cyclic GMP-AMP synthase antibody h-cGAS antibody Hypothetical protein LOC115004 antibody Mab 21 domain containing 1 antibody Mab-21 domain-containing protein 1 antibody MB21D1 antibody MGC131892 antibody MGC142166 antibody MGC142168 antibody OTTHUMP00000016743 antibody OTTHUMP00000039330 antibody protein MB21D1 antibody Uncharacterized protein C6orf150 antibody
Abbreviation: CGAS
Swiss Prot: Q8N884 Human, Q8C6L5 Mouse
Cellular Locus: Cell membrane, cytosol, nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat, Pig
Immunogen: Synthetic peptide within C-terminal human cGAS.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: MCF-7 cell lysate, THP-1 cell lysate, Hela cell lysate, rat lung tissue lysate, A431, LOVO, SKOV-3, L-929, human colon carcinoma tissue, human uterus tissue, mouse kidney tissue, rat bladder tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:100-1:500
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 59 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for cGAS Rabbit Polyclonal Antibody?

The catalog number for cGAS Rabbit Polyclonal Antibody is HA500023.

What sizes are available for cGAS Rabbit Polyclonal Antibody?

cGAS Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is cGAS Rabbit Polyclonal Antibody in stock?

cGAS Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is cGAS Rabbit Polyclonal Antibody used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.