ASNA1 Rabbit Polyclonal Antibody

About this product

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.

Specifications

Catalog number

HA500051

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ARSA 1 antibody ARSA antibody ArsA arsenite transporter ATP binding homolog 1 antibody ArsA arsenite transporter, ATP binding, E. coli, homolog of, 1 antibody ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial) antibody ARSA I antibody ARSA-I antibody ARSA1 antibody ARSAI antibody Arsenical pump driving ATPase antibody Arsenical pump-driving ATPase antibody Arsenical resistance ATPase antibody Arsenite translocating ATPase antibody Arsenite transporting ATPase antibody Arsenite-stimulated ATPase antibody ASNA 1 antibody ASNA I antibody ASNA-I antibody ASNA_HUMAN antibody ASNA1 antibody Asna1 protein antibody ASNAI antibody ATPase ASNA1 antibody GET3 antibody Golgi to ER traffic 3 homolog antibody hARSA-I antibody hASNA-I antibody MGC3821 antibody Transmembrane domain recognition complex 40 kDa ATPase subunit antibody Transmembrane domain recognition complex, 40kDa antibody TRC40 antibody

Abbreviation

ATPase GET3UniRule annotation Arsenical pump-driving ATPase Arsenite-stimulated ATPase Guided entry of tail-anchored proteins factor 3, ATPase Transmembrane domain recognition complex 40 kDa ATPase subunit hARSA-I hASNA

Swiss Prot

O43681 Human, G3V9T7 Rat

Cellular Locus

Cytoplasm, Endoplasmic reticulum, Nucleus.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within human ASNA1 aa 300-348.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

MCF-7 cell lysate, 293T cell lysate, rat kidney tissue, human thyroid tissue, human pancreas tissue, human rectal cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No