Smg1 Rabbit Polyclonal Antibody — image 1 of 3

Product details

Smg1 Rabbit Polyclonal Antibody

Catalog number HA500054

Price for HA500054

Size / count 100 µL

About this product

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

Specifications

Catalog number: HA500054
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 61E3.4 antibody ATX antibody hSMG-1 antibody hSMG1 antibody KIAA0421 antibody Lambda interacting protein antibody Lambda-interacting protein antibody Lambda/iota protein kinase C interacting protein antibody Lambda/iota protein kinase C-interacting protein antibody LIP antibody Phosphatidylinositol 3 kinase related kinase antibody Phosphatidylinositol 3 kinase related protein kinase antibody PI 3 kinase related kinase SMG 1 antibody Serine/threonine protein kinase SMG1 antibody Serine/threonine-protein kinase SMG1 antibody SMG-1 antibody smg1 antibody SMG1_HUMAN antibody
Abbreviation: Serine/threonine-protein kinase SMG1 SMG-1 hSMG-1 61E3.4 Lambda/iota protein kinase C-interacting protein Lambda-interacting protein
Swiss Prot: Q96Q15 Human
Cellular Locus: Cytoplasm, Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within human Smg1 aa 3450-3661.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P
Positive Control: Hela cell lysates, human kidney tissue, human skeletal muscle tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:100-1:500
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 410/395/340/269 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Smg1 Rabbit Polyclonal Antibody?

The catalog number for Smg1 Rabbit Polyclonal Antibody is HA500054.

What sizes are available for Smg1 Rabbit Polyclonal Antibody?

Smg1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Smg1 Rabbit Polyclonal Antibody in stock?

Smg1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Smg1 Rabbit Polyclonal Antibody used for?

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.