TMPRSS2 Rabbit Polyclonal Antibody

About this product

Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate . Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells . In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).By similarity3 Publications (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry . Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Specifications

Catalog number

HA500060

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

D16Ertd61e Epitheliasin FLJ41954 MGC6821 PP9284 PRSS10 Serine protease 10 TMPRSS2 TMPRSS2 ERG FUSION GENE, INCLUDED TMPRSS2 ETV1 FUSION GENE, INCLUDED TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain Transmembrane protease, serine 2 Transmembrane protease, serine 2, EC 3.4.219

Abbreviation

Transmembrane protease serine 2 Serine protease 10 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain

Swiss Prot

O15393 Human, Q9JIQ8 Mouse

Cellular Locus

Cell membrane, Membrane, Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human TMPRSS2 aa 300-350.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

PC-3M cell lysate, mouse colon tissue lysate, human stomach tissue, human pancreas tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,1000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 54 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No