RhoGDI Rabbit Polyclonal Antibody

About this product

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.

Specifications

Catalog number

HA500067

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ARHGDIA antibody fa96g11 antibody GDIA 1 antibody GDIA1 antibody GDIR1_HUMAN antibody MGC117248 antibody NPHS8 antibody Rho GDI 1 antibody Rho GDI alpha antibody Rho GDI antibody Rho GDP dissociation inhibitor (GDI) alpha antibody Rho GDP dissociation inhibitor 1 antibody Rho GDP dissociation inhibitor alpha antibody Rho GDP-dissociation inhibitor 1 antibody Rho-GDI alpha antibody RhoGDI 1 antibody RhoGDI alpha antibody RHOGDI antibody RhoGDI1 antibody wu:fa96g11 antibody zgc:55554 antibody zgc:77681 antibody

Abbreviation

ARHGDIA

Swiss Prot

P52565 Human, Q99PT1 Mouse, Q5XI73 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human RhoGDI aa 50-204.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HepG2 cell lysate, SH-SY5Y cell lysate, rat lung tissue lysate, MG-63, SH-SY5Y, rat testis tissue, human lung tissue, human thyroid tissue, mouse thyroid tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 23 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No