CHMP2A Rabbit Polyclonal Antibody

About this product

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Specifications

Catalog number

HA500070

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

BC 2 antibody BC2 antibody Charged multivesicular body protein 2a antibody CHM2A_HUMAN antibody CHMP2 antibody CHMP2a antibody Chromatin modifying protein 2a antibody Chromatin-modifying protein 2a antibody hVps2 1 antibody hVps2-1 antibody putative breast adenocarcinoma marker antibody Putative breast adenocarcinoma marker BC-2 antibody Putative breast adenocarcinoma marker BC2 antibody Vacuolar protein sorting associated protein 2 1 antibody Vacuolar protein sorting-associated protein 2-1 antibody Vps2 1 antibody VPS2 antibody Vps2-1 antibody VPS2A antibody

Abbreviation

CHMP2A

Swiss Prot

O43633 Human, Q9DB34 Mouse, B2RZB5 Rat

Cellular Locus

Late endosome membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N-terminal human CHMP2A.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

SW480 cell lysate, A431 cell lysate, HepG2 cell lysate, rat bladder tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:100;IHC-P: 1:200-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size:25 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No