DDX3 Rabbit Polyclonal Antibody

About this product

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.

Specifications

Catalog number

HA500093

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ATP dependent RNA helicase DDX3X antibody ATP-dependent RNA helicase DDX3X antibody CAP Rf antibody DBX antibody DDX14 antibody DDX3X antibody DDX3X_HUMAN antibody DEAD (Asp Glu Ala Asp) box polypeptide 3 X linked antibody DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked antibody DEAD box antibody DEAD box protein 3 antibody DEAD box protein 3 X-chromosomal antibody DEAD box X isoform antibody DEAD box, X isoform antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3 antibody DEAD/H box 3 antibody DEAD/H box 3, X-linked antibody Helicase like protein 2 antibody Helicase-like protein 2 antibody HLP2 antibody X isoform antibody X-chromosomal antibody

Abbreviation

DDX3X

Swiss Prot

O00571 Human, Q62167 Mouse

Cellular Locus

Inflammasome, Centrosome, Cell membrane, Nucleus, Cytoplasm, Stress granule, Lamellipodium.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human DDX3 aa 220-420.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

NIH/3T3 cell lysate, K562 cell lysate, A431 cell lysate, HepG2 cell lysate, Jurkat cell lysate, rat testis tissue lysate, A549, LOVO.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

73 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No